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Pick a Lock
The GM might call for a Dexterity check when you try to pick a lock. (80) There is no Dexterity-based skill associated with picking a lock.
Trying to pick a lock requires proficiency with thieves’ tools. (79) Home Rule: In rare situations an improvised tool might work (but you would still need proficiency with thieves' tools).
Can I pick a lock more than once?
Trigger a trap when picking a lock.
Break a lock or locked door.
Use the knock spell or chime of opening rather than pick a lock.
The arcane lock spell increases the DC to pick a lock by 10.